![]() ![]() Photosynthesis of previtamin D 3 in human skin and the physiologic consequences. Holick MF, MacLaughlin JA, Clark MB, et al. Rickets including osteomalacia and tetany. The induction of growth-prompting and calcifying properties in a ration exposed to light. The reduction of growth-promoting and calcifying properties in a ration by exposure to ultraviolet light. Antirachitic properties imparted to inert fluids and to green vegetables by ultraviolet irradiation. The cure of infantile rickets by sunlight. Heilung von Rachitis durch Kunstliche Hohensonne. Proceedings of a Symposium Basel, Switzerland 1998 Nov 1–3, 1998 Boston: Kluwer Academic Publishers 1999. Biologic effects of light: historical and new perspectives. The geographical distribution and aetiology of rickets. Jerdrzej Sniadecki (1768–1838) on the cure of rickets. Resurrection of vitamin D deficiency and rickets. Vertebrate endocrinology: fundamentals and biomedical implications, vol. Phylogenetic and evolutionary aspects of vitamin D from phytoplankton to humans. There needs to be a renewed appreciation of the beneficial effect of moderate sensible sunlight for providing all humans with their vitamin D requirement for health. The vitamin D deficiency pandemic has other serious consequences including increased risk of common cancers, autoimmune diseases, infectious diseases, and cardiovascular disease. Vitamin D deficiency causes growth retardation and rickets in children and will precipitate and exacerbate osteopenia, osteoporosis and increase risk of fracture in adults. This deficiency is in part due to the inadequate fortification of foods with vitamin D and the misconception that a healthy diet contains an adequate amount of vitamin D. Vitamin D deficiency was thought to have been conquered, but it is now recognized that more than 50% of the world’s population is at risk for vitamin D deficiency. ![]() Skin pigment, sunscreen use, aging, time of day, season, and latitude dramatically affect previtamin D 3 synthesis. Most humans have depended on sun for their vitamin D requirement. During exposure to sunlight, the ultraviolet B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D 3 which in turn is isomerized by the body’s temperature to vitamin D 3. Vitamin D is the sunshine vitamin for good reason. ![]()
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